Patients should receive comprehensive education about injection technique for GLP-1 receptor agonists (if applicable), proper medication storage, and the importance of adherence
Dopaminergic neurons are especially prone to ferroptotic damage, partly because dopamine metabolism itself can generate reactive quinone species, contributing to oxidative stress
Oxidative stress refers to a serious imbalance between the oxidant species that are produced by metabolism and the effective action of the antioxidant system, and this imbalance can cause severe oxidative damage in cells
Best practice: Match the compound to the specific cellular pathway (Systemic energy/insulin = MOTS-c, Targeted NAD+/fat loss = 5-Amino-1MQ)
24,29 Through this receptor, GLP-1 leads to an increase of cAMP levels that thereafter activates protein kinase A (PKA)
Especially during diet and definition phases, , an adequate supply of L-Carnitine is important