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However, tirzepatide is the medication associated with the case report of induced thyroiditis mentioned earlier

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89 The exact mechanism is unknown but with the existing evidence, it is reported that metformin acts by elevating NO availability, restricting interstitial fibrosis and deposition of AGE products, and restraining apoptosis of cardiomyocytes leading to diminished cardiac remodeling, and these effects conserve the systolic/diastolic functions of left ventricle hence minimizing the propensity to cause heart failure

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