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Potential Side Effects and Risks of GLP-1 RAs Whilst highly effective, GLP-1 receptor agonists are not without side effects

Retatrutide's higher weight-loss ceiling exists because glucagon receptor agonism adds a second, parallel fat-loss pathway that tirzepatide and semaglutide do not engage

All of the dynamics around GLP-1s, compounding shortage workarounds, and potential for DTC telehealth fallout I described last August seem to be playing out in 2025

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Who Can Prescribe Compounded GLP-1 Medications

Understanding the long-term outcomes is critical for groups who are considering adding these therapies to coverage for weight loss so they can assess whether covering the cost of these therapies for their employees is affordable when long-term adherence and reduction in medical spend has yet to be established. Blue Cross and Blue Shield of Kansas continuously monitors the pharmacy landscape to determine the best course of care for members