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J Clin Invest (2018) 128(7):2691701
Immune checkpoint blockade induces distinct alterations in the microenvironments of primary and metastatic brain tumors
Several agents with GAG-like properties, such as sodium hyaluronate, heparin, and pentosan polysulfate, are administered intravesically as treatment for IC/BPS, based on the hypothesis that replenishing the GAG layer might lead to urothelial layer recovery