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Preliminary clinical observations and animal studies indicate that semaglutide can reduce overall craving and intake of alcohol and addictive substances by acting on the mesolimbic dopamine system, thereby opening a brand-new perspective for drug repurposing. Driven by these clinical needs and the latest R&D trends, WuXi Biology conducted efficacy studies of semaglutide in animal models of AUD and Cocaine Use Disorder (CUD)

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Because retatrutide remains under clinical investigation rather than broad commercial approval, dosage research should always be understood within scientific, regulatory, and safety-focused frameworks