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L., Saleh, M

For type 2 diabetes , NICE guideline NG28 recommends GLP-1 receptor agonists in specific circumstances, including: As part of triple therapy (with metformin and either a sulfonylurea or pioglitazone) when dual therapy with metformin and another oral drug has not achieved adequate glycaemic control As part of triple therapy with metformin and a sodium-glucose cotransporter 2 (SGLT2) inhibitor if certain criteria are met In combination with insulin, with or without other antidiabetic drugs Treatment should be continued only if there is a beneficial metabolic response (reduction of at least 11 mmol/mol in HbA1c and weight loss of at least 3% at 6 months)

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Additionally, some sources suggest that berberine in combination with the blood pressure-lowering medication amlodipine may reduce blood pressure more than medication alone, and a clinical trial on adults with metabolic syndrome taking 500 mg of berberine three times a day resulted in decreased systolic blood pressure (along with other metabolic improvements, like lower triglycerides and blood glucose and improved insulin sensitivity)

2228 g) and Wistar rats (9- to 10-week-old