Its possible immune checkpoint inhibitors dont work well in these tumors because they are turning on ACK1 , which suppresses the immune response
A key limitation in translating these benefits into clinical practice lies in the low bioavailability of polyphenols
A biofeedback system of baroreceptor cardiac reflex sensitivity
doi: 10.1073/pnas.0912059107 19 LeeJHPhelanPShinMOhBCHanXImSSet al
While beneficial for normal growth, it poses a theoretical risk of accelerating the growth of existing or dormant cancers (for example, prostate, breast, colon) by inhibiting apoptosis (programmed cell death) and driving cell replication
this is because VAT contains more immune cells compared to subcutaneous fat and the main immune cell types in VAT are ATMs and T cells, which play a more critical role in immune metabolic homeostasis (151)