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Due to concerns regarding potential bone loss accompanying substantial weight reduction, further research is needed to determine the long-term effects of cagrilintide-semaglutide on bone mineral density, bone turnover, and fracture risk

In addition to controlling obesity and type 2 diabetes, two key cardiovascular risk factors, GLP-1RAs may stabilise atherosclerotic plaques, mitigate post-prandial hyperlipidaemia, and reduce sympathetic nervous system activity that contributes to elevated blood pressure

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Circulating factors are involved in hypoxia-induced hepcidin suppression