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If there is additional stress I notice different thingshowever, I have late stage Lyme disease and it doesnt take much to disturb it and experience symptoms that are not related to my need for sufficient adequate B intake

For instance, a balanced intake of iodine, selenium, vitamin D and essential fatty acids is important to protect thyroid functions

(2018) Kleinman and Sosne (2016) Philp et al

Moutsatsou P, Tsoporis JN, Salpeas V, Bei E, Alevizos B, Anagnostara C, et al

And bacterial contamination becomes a risk once preservatives in the solution begin to degrade, which happens faster at higher temperatures

10.1161/STROKEAHA.111.000309 253