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Most notably, insulin often causes weight gain in patients, whereas GLP-1 analogs actually promote weight loss

And in the brain, it crosses the blood-brain barrier and activates anorexigenic neurons in the hypothalamus, specifically the POMC/CART pathways that signal fullness while suppressing the NPY/AgRP pathways that drive hunger

In a single-center pilot study, 20 obese patients with LVEF40% and NYHA class III or IV heart failure were divided to receive a continuous subcutaneous infusion of GLP-1 or a small volume of saline as a control over 5 weeks

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administration, oral absorption was significantly faster and bioavailability was lower (and therefore more variable) [22]