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The increase in energy expenditure could be explained by enhanced levels of PPAR-, PGC-1, and uncoupling protein-1 (UCP-1) in BAT as well as elevated levels of proopiomelanocortin in the hypothalamus

Butyrate binds to the L-cell receptors that triggers GLP-1 release

Animals Adult male (n=68) and female (n=68) SpragueDawley rats were bred in house from breeding pairs obtained from Charles River, Quebec, Canada, after weaning rats were double-housed in a 12-h light/dark cycle

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However, monitor blood sugar closely as the combined glucose-lowering effects may be stronger with tirzepatide than they were with semaglutide