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Walker, MD Saint Francis Medical Center NASS Patient Safety Committee Member Cape Girardeau, MO Introduction and Mechanism of Action Glucagon-like peptide-1 (GLP-1) agonists are recognized for their efficacy in managing diabetes mellitus and aiding weight loss.1 They also reduce cardiovascular risk.2,3,4 The mechanism of action involves mimicking GLP-1, an incretin hormone that enhances insulin secretion after an oral glucose load.5,6 Beyond these effects, GLP-1 agonists are involved in inhibiting glucagon secretion, thus stabilizing blood glucose levels

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Providers typically follow established titration schedules to allow tolerance to develop

cGKI-deficient mice are characterized by enhanced eryptosis, anemia, and splenomegaly with accumulation of PS-exposing erythrocytes in the spleen [175]

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