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For example, patients with large-artery atherosclerotic stroke and transient ischemic attack displayed obvious intestinal dysbacteriosis and reduced blood TMAO levels (Yin et al., 2015)

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[1] It has also been studied, in NIH-funded research, for HIV-associated fatty liver disease (NAFLD/MASLD), and earlier in its development program it was investigated for indications as varied as wasting, sleep, and mild cognitive impairment most of which did not advance

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Introducing two powerful variables at once creates a cascade of effects that are, as of today, completely unstudied in any formal clinical setting