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During GLP-1 therapy, insulin sensitivity typically improves and glucagon secretion normalizes
Patients with certain FTO and MC4R variants may benefit from earlier dose progression or dual-compound protocols like GLP-Squared, while others achieve target weight loss with lower, sustained dosing
Effects of two antioxidants
Clinical trials such as the STEP (Semaglutide Treatment Effect in People with Obesity) program have demonstrated that semaglutide can produce substantial and sustained weight loss , often exceeding 1015% of baseline body weight when combined with lifestyle modification
It reduces pain and swelling by lowering prostaglandin production in the body