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This rising trend extends beyond older adolescents to include younger age groups, with a particularly alarming increase observed in the rates of severe and extreme obesity, which are associated with a subsequent increase in cardiovascular risk [3,4,5,6]

In 1857, Virchow formally put forward the concept of melanosis coli.7 MC is becoming increasingly common because there are many pathological conditions of the bowel that prompt the use of anthraquinone laxatives.8 To promote a better understanding of MC, we will summarize the recent progress made in MC research

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