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Gastrointestinal effects usually settle across the first month, then return temporarily after each increase

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IGF-1's suppression of GH secretion through negative feedback indirectly improves metabolic function by reducing GH-mediated lipolysis and its associated insulin-antagonistic effects

In response to its potential hazards, several regulatory strategies have been proposed, including promoting the recovery of butyrate-producing bacteria, such as Faecalibacterium , to competitively inhibit its proliferation and optimizing the gut microbiome structure through probiotic supplementation and dietary fiber interventions 142

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