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Expression of the Glucagon-Like Peptide-1 Receptor and Its Role in Regulating Autophagy in Endometrial Cancer

Consider semaglutide if: You prioritize lower cost and established safety data You have a history of GI sensitivity and prefer gradual titration You want to start with the more affordable option (semaglutide at $299/month) You're seeking 15-18% weight loss with solid cardiovascular benefit Consider tirzepatide if: You have more aggressive weight loss goals (20%+ reduction) You have type 2 diabetes or significant cardiometabolic risk Cost is not a primary barrier You tolerate GI side effects well or are willing to manage them Many patients find success on either medication

These thresholds are lower than Western standards due to higher cardiometabolic risk at lower body mass index levels in South Asian populations

A muscle-preserving GLP-1 plan should include: Protein at each meal Resistance training at least several days per week when medically appropriate Walking or low-impact movement Hydration and electrolyte support when needed Adequate sleep Monitoring for fatigue or weakness Avoiding overly restrictive dieting Adjusting the medication dose if appetite suppression becomes too strong The goal is not simply to weigh less

Front Behav Neurosci [Internet]

High levels of GFAP are also noted in glaucoma