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This review aims to provide investigators in the field with comprehensive and cutting-edge theoretical insights and research directions

Marashly, [email protected] Specialty section: This article was submitted to Neurodegeneration, a section of the journal Frontiers in Neurology Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

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Palmieri, E

Despite promising Phase 2 results and an excellent safety profile, the compound could not demonstrate sufficient efficacy in the larger confirmatory trial to justify the investment required for continued pharmaceutical development toward regulatory approval

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