The ensuing burst of lipid peroxides accelerates ferroptosis, revealing that Cu + can indirectly propagate the ROS-lipid peroxidation cascade of ferroptosis
95 Recently, it has been demonstrated that PYY 3-36 is also produced by neurons of the paraventricular nucleus (PVN), ARC, and supraoptic nuclei of the human hypothalamus
Consistent with this context-dependent framework, lifestyle factors further contribute to metabolic heterogeneity in PCOS, as dietary patterns characterized by higher fat intake, greater consumption of medium/high glycemic index foods, and lower physical activity have been associated with increased insulin resistance and inflammation, whereas higher fiber intake shows protective associations with metabolic markers [123]
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