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71,72,73,76 One obstacle to preclinical use in animal models is the species specificity of the drug

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Generally, the injection is prepared by mixing the ampoule and vial contents with sterile water, followed by administration via IV line or butterfly syringe

As all species involved in this catalytic mechanism (NADPH, FAD, disulfide pairs, and oxidants) are redox active and it was determined that all discerned states were quasi-equilibrium states that include combinations of extents of oxidation and reduction for all redox active species

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