Studies of endogenous GLP-1 release and administration of long acting GLP-1 agonists show two mechanisms of action (78)
GIP receptor signaling contributes through partly separate pathways: it influences energy balance, adipose-tissue handling of nutrients, and central appetite circuits, and it may temper the nausea that GLP-1 agonism can provoke
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Some people notice their weight dropping quickly in the first few weeks due to weight loss and appetite reduction, but its important to maintain realistic expectations on average, you will see around 1 to 2 pounds of weight loss per week after the initial phase