The treatment effects of interest, including the differences in the respective primary endpoints of interest from baseline to the defined primary timepoint, will be summarized using an analysis of covariance (ANCOVA) for the treatment regimen estimand and a mixed model for repeated measures (MMRM) for the efficacy estimand, both with treatment and strata as fixed effects and the baseline response variable as a covariate
Factors like blood sugar, insulin resistance, other conditions, and your goals all shape the decision, which is why supervision matters
Especially because of their impact on managing weight and overall metabolic well-being
The conversations we have around skin are more about refinement
When inflammation decreases, depression often improves even before significant weight loss occurs
In most cases, a simple and repeatable system is easier to maintain long-term, especially as appetite and eating patterns continue to change on GLP-1 medications