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According to one hypothesis, p21 acts on GSH, thereby increasing the synthesis of GSH and GPX4, decreasing lipid peroxide accumulation, and reducing cell sensitivity to ferroptosis

This mechanism, while beneficial in controlled doses, can quickly become dangerous in cases of overdose, leading to a cascade of physiological responses that may require emergency intervention

doi: 10.1002/hsr2.291 39 ChenPWangDXiuMChenDLackeyBWuHEet al

The HSD17B1, HSD17B3, ARK1C3 (also known as HSD17B5), HSD17B7, HSD17B12, and RDH11 (also known as HSD17B15) enzymes all function in some capacity in the metabolism of steroids

Both main processing steps during traditional injera preparation, i.e., fermentation mostly by lactic acid bacteria and baking, led to folate reduction