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In some cases, a few amino acids act as the substrate for the biosynthesis of other amino acids

Inflammopharmacology 31:25992614 Kawaguchi S, Fujiwara S-i, Murahashi R, Nakashima H, Matsuoka S, Ikeda T, Toda Y, Ito S, Ban T, Nagayama T (2021) Risk factors for high-dose methotrexate-induced nephrotoxicity

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In a collagen-induced arthritis (CIA) model, kaempferol was found to reduce the quantity of pathogenic CD4+ effector memory T cells while increasing nave T cells and Tregs, thereby ameliorating the condition (180), while berberine and rutin augment Treg activity to assist in the management of RA (181)