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Results from the phase 2 TROPION-Lung05 trial published in the Journal of Clinical Oncology revealed that among 137 patients given 6 mg/kg of dato-DXd every 21 days for pretreated NSCLC, the confirmed ORR was 35.8% (95% CI, 27.8%-44.4%), including 32.8% of patients experiencing a partial response and 2.9% having a complete response

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Construction and evaluation of brain-specific Insr-knockout mice (C57BL/6J-Insr em1cyagen ) Brain-specific Insr-knockout mice were generated by using Cre-loxP system 59