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It was first identified in 2015 and is encoded by a short open reading frame within the mitochondrial 12S rRNA gene

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Revised: Mar 2025 Side Effects for Egrifta WR The following important adverse reactions are also described elsewhere in the labeling: Increased risk of neoplasms [see WARNINGS AND PRECAUTIONS ] Elevated IGF-1 levels [see WARNINGS AND PRECAUTIONS ] Fluid retention [see WARNINGS AND PRECAUTIONS ] Glucose intolerance or diabetes mellitus [see WARNINGS AND PRECAUTIONS ] Hypersensitivity reactions [see WARNINGS AND PRECAUTIONS ] Injection site reactions [see WARNINGS AND PRECAUTIONS ] Clinical Trial Experience Because clinical trials are conducted under widely varying conditions, adverse reaction rates observed in the clinical trials of a drug cannot be directly compared to rates in the clinical trials of another drug and may not reflect the rates observed in practice

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