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Over a period of time, KD has been evaluated in 2 uncontrolled and 1 placebo-controlled clinical trial, while AMD has been evaluated in 1 clinically controlled open-labeled clinical trial for its efficacy against ASD [165]

Moreover, last year a separate study showed that 91% of obese individuals receiving a weekly dose of 15 mg Tirzepatidea recently developed GLP-1R/GIPR dual agonist, lost 5% of their body mass with 36% of participants on the same dosage losing at least 25% ( While these data are astoundingwith yearly progress in efficacy, we should consider that around 9% of patients receiving these game-changer treatments (Table 1)

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