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On the other hand, metabolic syndrome (MetS) is a constellation of symptoms that implies a higher risk for CVD and type 2 diabetes (T2D), increasing the morbidity and mortality of these patients

However, the SPH domain lacks proteolytic activity due to a mutation of the catalytic residues

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Tesamorelin + Ipamorelin : Tesamorelin is an FDA-approved GHRH analog (Egrifta) with a shorter half-life (~26 min)

Ipamorelin and GHRP-6 increase bone mineral content in adult rats as measured by DXA (Svensson et al., 2000)