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2 Results 2.1 Pharmacokinetic studies of BPC157 in rats The effective dose of BPC157 for the treatment of various injuries in mice, rats, and rabbits ranges from 6 to 50 g/kg ( The mean (+SD) plasma concentration of BPC157 versus time curves following administration of various BPC157 doses in rats are shown in Figures 1AC, and the corresponding pharmacokinetic parameters are presented in Tables 1Tables 3

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Although cholestasis is a generically toxic insult to the liver that can cause cirrhosis, several diseases that are characterized by cholestasis seem to be caused by underlying immune or inflammatory disorders affecting either small (primary biliary cirrhosis [PBC]) or large (primary sclerosing cholangitis [PSC]) bile ducts

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