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In the key pre-marketing clinical trial of the drug, 1961 people who participated in the clinical trial lost an average of 9% of their body weight after 20 weeks, and an average of 14.9% after 68 weeks, of which 1/3 of the patients lost 20% or 46 pounds or more

Additionally, it strengthens the skin barrier and improves hydration, making skin smoother and more resilient

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99 Although these results could have been influenced by the short length of treatment compared to other studies, which observed participants for more than 10 weeks, they highlight the need for tailored studies considering the different comorbidities to identify patients who could benefit the most from these therapies

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Berberine, for instance, shouldn't be combined with certain diabetes medications without medical supervision