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The SURMOUNT-4 trial demonstrated that participants who discontinued tirzepatide after initial weight loss regained significant weight (approximately 14% regain over 52 weeks following randomized withdrawal), while those continuing treatment maintained their weight loss, confirming ongoing medication efficacy

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Using a rat model of 2-butoxyethanol induced hemolytic anemia associated with systemic thrombosis, fibrin thrombi were noted in the central vein and sinusoids of the liver, in addition to the presence of thrombi seen in several other organs (Ramot et al

These agents often possess multi-targeted actions, addressing several facets of MIRI pathophysiology simultaneously

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