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During GLP-1R blockade, infusion of glucose was immediately required upon starting GLP-1m infusions in all subjects due to a more dramatic reduction in HGP, as well as a delayed and modest insulinotropic response

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However, using an ECD-binding antibody Fab fragment (Fab7F38) for co-crystallization, we successfully crystallized the GLP-1RPF-06372222Fab7F38 complex

doi: 10.1016/j.apsb.2022.06.003 56 ChiouHYCLinMWHsiaoPJChenCLChiaoSLinTYet al