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Research stage: Primarily animal studiesvery limited human clinical trials

doi: 10.2164/jandrol.111.013193 92 CannarellaRCrafaACurtoRCondorelliRALa VigneraSCalogeroAE

Comparatively, ipamorelin may induce significant GH pulses, particularly at higher doses

An RCT of 174 patients with severe alcoholic hepatitis found that the combination of prednisolone + NAC (IV for 5 days, then oral for 2 weeks) significantly reduced 1-month mortality compared to prednisolone alone (8% vs 24%, p=0.006), though the difference was not significant at 6 months (Nguyen-Khac et al., N Engl J Med, 2011) [36]

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In addition to its classical GHS-R1a activity, hexarelin also binds to the CD36 receptor expressed on cardiomyocytes and the cardiac microvascular endothelium