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Different PPIs bind to varying cysteine residues of the H + /K + ATPase allowing for slightly different properties of the PPIs (Shin and Sachs 2008)
This is the process that underlies the transition of a person from being insulin-resistant to prediabetic
JAMA 12 , 22112223 (2017)
Hers recently moved away from compounded GLP-1s and now focuses on brand-name medications only - things like Wegovy, Zepbound, Ozempic, and Mounjaro
If you are seeing a patient whose musculoskeletal presentation does not quite match a plausible mechanism of injury or evolves in unexpected ways, it is worth keeping an endocrine disorder on your clinical radar
Holman N, Knighton P, Kar P, O'Keefe J, Curley M, Weaver A, Barron E, Bakhai C, Khunti K, Wareham NJ, Sattar N (2020) Risk factors for COVID-19-related mortality in people with type 1 and type 2 diabetes in England: a population-based cohort study
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