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On the other hand, also downregulation of Eph receptors can lead to increased metastasis as shown for EphA1 in colorectal cancer, EphA7 in prostate carcinomas, and EphB6 in melanoma [160, 161]

These include disruptions in iron metabolism, oxidative stress imbalances, altered intracellular signaling, and changes to the local microenvironment

Anwar, D

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Beyotime Biotechnology, Shanghai, China)