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The isovaleric acid was found to have a causal link between signs of depression and blood cortisol levels and appears to inhibit neurotransmitter release in the synaptic cleft (174)

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Circ Heart Fail 12(3):e005234 da Silva MG, Mattos E, Camacho-Pereira J, Domitrovic T, Galina A, Costa MW, Kurtenbach E (2012) Cardiac systolic dysfunction in doxorubicin-challenged rats is associated with upregulation of MuRF2 and MuRF3 E3 ligases

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