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Whilst this NMA addresses a range of efficacy and safety outcomes, the primary goals of the studies included in the NMA were to assess weight reduction and safety outcomes, rather than cardiovascular, hepatic or renal factors

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The spectrum of oral lesions can include melanin-associated and exogenous pigmented lesions such as physiologic pigmentation and an amalgam tattoo, reactive processes such as smokers melanosis and post-inflammatory pigmentation, benign neoplasms such as melanocytic nevi, and malignant conditions such as oral mucosal melanoma