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In a relatively recent review by Al-Samerria and Radovick [9], the role of IGF-1 in the regulation of the GH-axis was addressed

Acute cisplatin ototoxicity paradigm: Under anesthesia, animals received a single intraperitoneal injection of cisplatin (12-14 mg/kg) over a 30-min period

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Therefore, while elevated total antibodies might reflect a broad immune response, the presence of TRAb indicates a more targeted autoimmune phenomenon rather than a nonspecific antibody surge