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These experiments demonstrated that the relatively low dose of MK-801, required for achieving a synergistic weight loss by the conjugate, does not affect the body temperature after 14 days of repeated dosing, as none of the treatment groups displayed different core temperature compared with the vehicle-treated mice (Extended Data Fig
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However, the most definitive sign of degradation is a loss of expected efficacy or inconsistent results in your research application.
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In other study, exogenous spermidine increased AsA and GSH contents, activities of APX, DHAR, GR and CAT which reduced ROS production and oxidative stress under aluminium stress (Nahar et al
