References: Reynolds, J
Metabolic memory phenomenon and accumulation of peroxynitrite in retinal capillaries
Efficacy plateaus above 500mg per administration
However, the lifestyle intervention guidelines, dating back to 20072008, do not address the need to precisely measure dose, frequency, and type of physical activity or diet and do not suggest ways (e.g., cardiopulmonary exercise testing) other than self-report to monitor intervention compliance or fidelity
However, the effect of liver damage on drug exposure is small, meaning that the therapeutic dose does not need to be changed
A lack of education and resources, taken alongside a generally lower level of baseline strength in older females compared to males, may deter females from initiating participation in RT programs and further promote the age-related loss in muscle and physical independence that disproportionately affects older females (de Jong et al., 2023)