Unlike typical nonsteroidal anti-inflammatory drugs, acetaminophen has only a minor effect on tissue cyclooxygenase activity and appears to produce analgesia by increasing pain thresholds, perhaps through inhibition of the nitric oxide pathway that is activated by many pain neurotransmitter receptors
They can have an opposite effect (most commonly) or parallel effect (note, this parallelism occurs with quite distinctive models, i.e., amphetamine-effect [70], miosis [91], atropine-mydriasis [91], huge magnesium over-dose [85], ischemic/reperfusion colitis [49], duodenal congestion lesions [251], cecum perforation [174])
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