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No clinical trial has linked BPC-157 to insomnia, but its documented effects on dopamine D2 and serotonin pathways provide a plausible mechanism for sleep disruption (Sikiri et al., J Physiol Paris, 1999)

Since then, hundreds of studies have examined its effects on tissue repair, inflammation, and healing

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Additionally, research has explored NAD+'s role in acute neurological injuries such as stroke and traumatic brain injury using experimental models, with studies suggesting that rapid NAD+ depletion following brain injury contributes to neuronal death and that NAD+ restoration may be neuroprotective in research models

IL-21 signaling in immunity