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GLP-1 receptor agonists were initially developed to improve glycemic control in type 2 diabetes by enhancing insulin secretion and inhibiting glucagon release, with additional effects on appetite regulation and gastric emptying later recognized as clinically relevant (Chao et al

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"Retatrutide for the treatment of obesity, obstructive sleep apnea and knee osteoarthritis." Diabetes, Obesity and Metabolism, 2026;28(1):83-93

One nuance worth being straight about: at later time points, some of that CRP and IL-6 drop tracked with weight loss, while some of the early benefit appeared before major weight change

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This list isn't exhaustive - your assigned clinician will review your full health history and current medications before making any prescribing determination