Safety limits: Trial data is not the same as an approved label
Smaller meals are easier to tolerate and less likely to trigger discomfort
When the volume gets high enough that a manual check on every claim isn't realistic, that's the point most practices bring in help
Winter CS, Simon M, Zorn ME (1987)
The FDAs response was to allow licensed compounding pharmacies, regulated facilities that produce medications under strict sterile conditions, to fill the gap during the shortage
has documented that when rifaximin is used at the dose used in the present study and orally administered to male rats, the maximum plasma concentration is almost equal to that observed with the clinical dose (1,100 mg/day) orally administered to patients with liver cirrhosis for 14 days