It does not constitute medical advice, diagnosis, treatment recommendations, regulatory guidance, or professional healthcare consultation
Statistical analysis Statistical analyses were performed using GraphPad Prism 10.5.0 (GraphPad Software, San Diego, CA, USA)
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NA, not assessed/reported
In apolipoprotein E knockout (ApoE - / - ) mouse models, it significantly reduces the area of atherosclerotic plaques and the formation of lipid necrotic cores, concurrently decreasing serum inflammatory factors (e.g., interleukin6, tumor necrosis factor) [368]
Controlled and uncontrolled studies using folinic acid, a reduced form of folate, have reported marked improvements in core and associated ASD symptoms in some children with ASD and folate related pathway abnormities