Tirzepatide can also disrupt sleep through GI discomfort, nausea, and the general metabolic shifts that accompany rapid weight loss
Semaglutide stimulates insulin secretion from the pancreas when blood glucose levels are elevated, whilst simultaneously suppressing the release of glucagon, a hormone that raises blood sugar
GLP-1 is a 30 amino acid peptide produced by the L cells, enteroendocrine cells of the distal ileum and colon, and GIP is a 4 amino acid peptide produced by the K cells of the duodenum and jejunum
Acta Pharmacol Sin (2019) 40:80113
Ali RM, Hamad HA, Hussein MM, Malash GF
It also helps regulate blood sugar by maintaining its activity in the body over a longer period