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View image online ( illustration showing action of a GLP-1 receptor agonist For the first time, a pharmacotherapy for overweight and obesity has been shown to reduce cardiovascular events in patients with established cardiovascular disease (CVD) in the absence of type 2 diabetes

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Exclude pregnant or breastfeeding women, anyone under 18, and people with liver or kidney disease, bipolar or seizure disorders, or B-vitamin sensitivity, since each carries real physiological risk outside a controlled setting