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Niacin can also have an antagonistic effect on gout medications: it elevates uric acid levels, which may counteract drugs like allopurinol or pegloticase that are meant to lower uric acid

Kraus, D., et al

Athletic testing considerations AOD 9604 appears on the World Anti-Doping Agency (WADA) prohibited list

It plays an important role in cellular energy production and the maintenance of keratin infrastructure

The FDA subsequently classified AOD-9604 within Category 2 of the bulk drug substance review process, and the compound was later withdrawn from that nomination in April 2026

Pale skin Heart palpitations Shortness of breath A smooth tongue Vision loss Constipation Loss of appetite Diarrhea Gas Vision loss Mental problems like depression, memory loss, or behavioral changes Nerve problems like numbness or tingling, muscle weakness, and problems walking