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Routes: intravenous (IV), intramuscular (IM) Administration frequency: weekly to biweekly Duration: short-term cycles or maintenance protocols Infusion rate must be controlled to minimize adverse reactions

Statistical analysis No statistical methods were used to pre-determine sample sizes, but our sample sizes are similar to those reported in previous publications 13,76 and standards in the field

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Contrarily to the other methods listed before, vaccine-based approaches do not only aim to target senescent cells in tissues, but also senescent immune cells, which can be responsible for age-related diseases 60

During the meeting, FDA staff scientists highlighted a general lack of quality data supporting safety and effectiveness

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