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This benefit is linked to its ability to cross the blood-brain barrier and support mitochondrial function in brain cells

468 Some studies have found that regulating the microglial metabolism could enhance the phagocytosis of A by microglia

More recently, however, MK-677 (Ibutamoren) a small-molecule GHS has emerged as an alternative that mimics many of the effects of these peptides

J Neurosci Res (2010) 88(2):391402

Abbreviations AACE: American Association of Clinical Endocrinologists AE: Adverse event CDS: Chinese Diabetes Society DPP-4i: Dipeptidyl peptidase-4 inhibitor ETD: Estimated treatment difference FAS: Full analysis set FPG: Fasting plasma glucose GLP-1RA: Glucagon-like peptide-1 receptor agonist PIONEER: Peptide Innovation for Early Diabetes Treatment SAE: Serious adverse event SAS: Safety analysis set SF-36v2: 36-item Short Form Health Survey (Acute Version) SMPG: Self-monitored plasma glucose References International Diabetes Federation (2021) IDF diabetes atlas, 10th edn

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